CYP1A1 Antibody
Product Specifications
Background
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
NCBI Gene ID
1543
Swiss Prot
P04798
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 200-460 of human CYP1A1 (NP_000490.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
Affinity purification
Positive Control
MCF7
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 63kDa
Fragment
IgG
Symbol
CYP1A1
Positive Control 2
BT-474
Positive Control 3
HCT116
Positive Control 4
Mouse lung
Positive Control 5
Mouse craniofacial
Positive Control 6
Mouse liver
NCBI Official Name
Cytochrome P450, family 1, subfamily A, polypeptide 1
NCBI Organism
Homo sapiens
Other Product Names
CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX
Tested Applications
WB, IHC
Physical Properties
Liquid
Curated Selection
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