TNFRSF11B Antibody
Product Specifications
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
NCBI Gene ID
4982
Swiss Prot
O00300
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 22-280 of human TNFRSF11B (NP_002537.3) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cell Cycle, Chemokines & Cytokines, Immunology, Signal Transduction
Purification
Affinity purification
Positive Control
293T
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 44kDa
Fragment
IgG
Symbol
TNFRSF11B
Positive Control 2
SW480
Positive Control 3
MCF7
Positive Control 4
NCI-H460
Positive Control 5
K-562
Positive Control 6
Mouse liver
NCBI Official Name
Tumor necrosis factor receptor superfamily, member 11b
NCBI Organism
Homo sapiens
Other Product Names
TNFRSF11B, OPG, TR1, OCIF
Tested Applications
WB, IHC, IF
Physical Properties
Liquid
Curated Selection
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