MMP9 Antibody, KO Validated

Product Specifications

Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.

NCBI Gene ID

4318

Swiss Prot

P14780

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 538-707 of human MMP9 (NP_004985.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Antibody is Knockout validated.

Field of Research

Apoptosis, Cancer, Cell Cycle, Signal Transduction

Purification

Affinity purification

Positive Control

B-cell

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 110kDa

Fragment

IgG

Symbol

MMP9

Positive Control 2

MCF7

Positive Control 3

K-562

Positive Control 4

SW480

Positive Control 5

Mouse liver

Positive Control 6

Mouse lung

NCBI Official Name

Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

NCBI Organism

Homo sapiens

Other Product Names

MMP9 Antibody : GELB, CLG4B, MMP-9, MANDP2, Matrix metalloproteinase-9, 92 kDa gelatinase

Tested Applications

WB, IF

Physical Properties

Liquid

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