CHIT1 Antibody

Product Specifications

Background

Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene.

NCBI Gene ID

1118

Swiss Prot

Q13231

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 217-466 of human CHIT1 (NP_003456.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Innate Immunity

Purification

Affinity purification

Positive Control

U-251MG

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 52kDa

Fragment

IgG

Symbol

CHIT1

Positive Control 2

293T

Positive Control 3

Mouse spleen

Positive Control 4

Mouse skeletal muscle

NCBI Official Name

Chitinase 1 (chitotriosidase)

NCBI Organism

Homo sapiens

Other Product Names

CHIT1, plasma methylumbelliferyl tetra-N-acetylchitotetraoside hydrolase, OTTHUMP00000217085, OTTHUMP00000217084, OTTHUMP00000217083, MGC125322, FLJ00314, chitotriosidase-1, chitinase-1, chitinase 1 (chitotriosidase), CHIT, CHI3, CHITD