ACVR2A Antibody

Product Specifications

Background

This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.

NCBI Gene ID

Swiss Prot

P27037

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human ACVR2A (NP_001607.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction, Stem Cell

Purification

Affinity purification

Positive Control

SW480

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 57kDa

Fragment

IgG

Symbol

ACVR2A

Positive Control 2

Mouse kidney

Positive Control 3

Rat testis

Positive Control 4

Rat ovary

NCBI Official Name

Activin A receptor, type IIA

NCBI Organism

Homo sapiens

Other Product Names

ACVR2A, ACTRIIA, Activin receptor type IIA, ACTRII, Activin A receptor type II, Activin receptor type-2A, ACTR-IIA, Activin A receptor, type II, Activin A receptor, type IIA, ACVR2