APBB1 Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

NCBI Gene ID

322

Swiss Prot

O00213

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 359-708 of human APBB1 (NP_663722.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

Affinity purification

Positive Control

Raji

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 63kDa

Fragment

IgG

Symbol

APBB1

Positive Control 2

Lovo

Positive Control 3

BT-474

Positive Control 4

A-549

Positive Control 5

Mouse brain

Positive Control 6

Mouse heart

NCBI Official Name

Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)

NCBI Organism

Homo sapiens

Other Product Names

APBB1, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65), FE65, MGC:9072, RIR, adaptor protein FE65a2, amyloid beta A4 precursor protein-binding, member 1, stat-like protein