CD151 Antibody

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.

GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24, CD151 antigen, CD151 antigen (Raph blood group), hemidesmosomal tetraspanin CD151, membrane glycoprotein SFA-1, platelet surface glycoprotein gp27, platelet-endothelial cell tetraspan antigen 3, platelet-endothelial tetraspan antigen 3, tetraspanin-24, tspan-24