IL12RB1 Antibody

Product Specifications

Background

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.

NCBI Gene ID

3594

Swiss Prot

P42701

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 25-305 of human IL12RB1 (NP_714912.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Chemokines & Cytokines, Immunology, Innate Immunity

Purification

Affinity purification

Positive Control

A-431

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 73kDa

Fragment

IgG

Symbol

IL12RB1

Positive Control 2

MCF7

Positive Control 3

Mouse liver

Positive Control 4

Mouse thymus

NCBI Official Name

Interleukin 12 receptor, beta 1

NCBI Organism

Homo sapiens

Other Product Names

IL12RB1, MGC34454, interleukin-12 receptor beta-1 chain, interleukin 12 receptor, beta 1, IL-12R-BETA1, IL12RB, IL-12 receptor beta component, CD212, IL12R