IL10RA Antibody
Product Specifications
Background
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
NCBI Gene ID
3587
Swiss Prot
Q13651
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 22-230 of human IL10RA (NP_001549.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Chemokines & Cytokines, Immunology, Innate Immunity
Purification
Affinity purification
Positive Control
K-562
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 72kDa
Fragment
IgG
Symbol
IL10RA
Positive Control 2
MCF7
Positive Control 3
Mouse brain
NCBI Official Name
Interleukin 10 receptor, alpha
NCBI Organism
Homo sapiens
Other Product Names
IL10RA, CDW210A, HIL-10R, IL-10R1, IL10R, CD210, CD210a
Tested Applications
WB, IHC, IF
Physical Properties
Liquid
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