STRADA Antibody, KO Validated
Product Specifications
Background
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25) . The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.
NCBI Gene ID
92335
Swiss Prot
Q7RTN6
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 25-210 of human STRADA (NP_699166.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Antibody is Knockout validated.
Field of Research
Cancer, Cell Cycle, Immunology, Signal Transduction
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 48kDa
Fragment
IgG
Applications Notes
WB: 1:1000 - 1:2000
Symbol
STRADA
NCBI Official Name
STE20-related kinase adaptor alpha
NCBI Organism
Homo sapiens
Other Product Names
LYK5, FLJ90524, PMSE, STRAD, LYK5, Stlk, NY-BR-96
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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