MSH6 Antibody, KO Validated

Product Specifications

Background

This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.

NCBI Gene ID

2956

Swiss Prot

P52701

Host

Rabbit

Reactivity

Human, Mouse, Monkey

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human MSH6 (NP_000170.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Antibody is Knockout validated.

Field of Research

Apoptosis, Cell Cycle

Purification

Affinity purification

Positive Control

HeLa

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 160kDa

Fragment

IgG

Symbol

MSH6

NCBI Official Name

MutS homolog 6

NCBI Organism

Homo sapiens

Other Product Names

GTBP, GTMBP, HNPCC5, HSAP, p16DNA mismatch repair protein Msh6, G/T mismatch-binding protein, mutS protein homolog 6, mutS-alpha 160 kDa subunit, sperm-associated protein