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NME1 Antibody, KO Validated

Product Specifications

Background

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.

NCBI Gene ID

4830

Swiss Prot

P15531

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 90 to the C-terminus of human NME1 (NP_000260.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Antibody is Knockout validated.

Field of Research

Apoptosis, Cancer, Cell Cycle, Neuroscience

Purification

Affinity purification

Positive Control

293T

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=18-185

Calculated Molecular Weight

Observed: 21kDa

Fragment

IgG

Symbol

NME1

NCBI Official Name

NME/NM23 nucleoside diphosphate kinase 1

NCBI Organism

Homo sapiens

Other Product Names

NME1, AWD, GAAD, NB, NBS, NDPK-A, NDPKA, NM23, NM23-H1, non-metastatic cells 1, protein (NM23A) expressed in, NDP kinase A, OTTHUMP00000174772

Tested Applications

WB, IHC, IF

Physical Properties

Liquid

Curated Selection

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