PPP1R12B Antibody

Product Specifications

Background

Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20) . Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011]

NCBI Gene ID

4660

Swiss Prot

O60237

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 660-930 of human PPP1R12B (NP_002472.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

Affinity purification

Positive Control

293T

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 110kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

PPP1R12B

Positive Control 2

U-87MG

NCBI Official Name

Protein phosphatase 1 regulatory subunit 12B

NCBI Organism

Homo sapiens

Other Product Names

MYPT2, PP1bp55, protein phosphatase 1 regulatory subunit 12B, myosin phosphatase target subunit 2, myosin phosphatase-targeting subunit 2, protein phosphatase 1, regulatory (inhibitor) subunit 12B