RUNX1T1 Antibody
Product Specifications
Background
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t (8;21) (q22; q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
862
Swiss Prot
Q06455
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 100-390 of human RUNX1T1 (NP_783554.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Transcription
Purification
Affinity purification
Positive Control
HepG2
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 67kDa
Fragment
IgG
Applications Notes
WB: 1:200 - 1:1000
Symbol
RUNX1T1
Positive Control 2
SH-SY5Y
NCBI Official Name
Runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
NCBI Organism
Homo sapiens
Other Product Names
RUNX1T1, CDR, ETO, MTG8, AML1T1, ZMYND2, CBFA2T1
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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