MED1 Antibody

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor- (TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.

CRSP1, CRSP20DRIP205, DRIP23PBP, PPARBP, PPARGBP, RB18A, TRAP22TRIP2, mediator of RNA polymerase II transcription subunit 1, ARC205, PPAR-binding protein, PPARG binding protein, TR-interacting protein 2, TRIP-2, activator-recruited cofactor 205 kDa component, p53 regulatory protein RB18A, peroxisome proliferator-activated receptor-binding protein, thyroid hormone receptor-associated protein complex 220 kDa component, thyroid hormone receptor-associated protein complex component TRAP22thyroid receptor interacting protein 2, vitamin D receptor-interacting protein 230 kD, vitamin D receptor-interacting protein complex component DRIP205