MPZ Antibody

Product Specifications

Background

This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN) . A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.

NCBI Gene ID

4359

Swiss Prot

P25189

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MPZ

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

Affinity purification

Positive Control

A375

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 27kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

MPZ

Positive Control 2

HT-1080

Positive Control 3

Mouse brain

Positive Control 4

Mouse heart

Positive Control 5

Rat brain

NCBI Official Name

Myelin protein zero

NCBI Organism

Homo sapiens

Other Product Names

MPZ, myelin protein zero (Charcot-Marie-Tooth neuropathy 1B), CHM, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, DSS, HMSNIB, MPP, P0, myelin protein zero, CMTDID