P27 KIP 1 Antibody
Product Specifications
Background
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4) .
NCBI Gene ID
1027
Swiss Prot
P46527
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of human p27 KIP 1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Immunology, Signal Transduction
Purification
Affinity purification
Positive Control
MCF7
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=16-728
Calculated Molecular Weight
Observed: 27kDa
Fragment
IgG
Symbol
CDKN1B
Positive Control 2
293T
Positive Control 3
HeLa
Positive Control 4
HepG2
Positive Control 5
Mouse lung
Positive Control 6
C6
NCBI Official Name
Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
NCBI Organism
Homo sapiens
Other Product Names
Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1, CDKN1B, KIP1
Tested Applications
WB, IHC, IF
Physical Properties
Liquid
Curated Selection
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