KNG1 Antibody
Product Specifications
Background
This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK) . HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
3827
Swiss Prot
P01042
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 148-427 of human KNG1 (NP_000884.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cell Cycle, Signal Transduction
Purification
Affinity purification
Positive Control
HepG2
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 45-48kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
KNG1
Positive Control 2
U-87MG
Positive Control 3
Mouse liver
Positive Control 4
Mouse kidney
Positive Control 5
Mouse heart
NCBI Official Name
Kininogen 1
NCBI Organism
Homo sapiens
Other Product Names
KNG1, BDK, KNG, BK
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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