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FXN / Frataxin Antibody, KO Validated

Product Specifications

Background

This nuclear gene encodes a mitochondrial protein which belongs to the FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA from 8-33 repeats to >90 repeats results in Friedreich ataxia. Alternative splicing results in multiple transcript variants.

NCBI Gene ID

2395

Swiss Prot

Q16595

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 42-210 of human FXN / Frataxin (NP_000135.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Antibody is Knockout validated.

Field of Research

Signal Transduction

Purification

Affinity purification

Positive Control

K-562

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 14kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

FXN

Positive Control 2

U-87MG

Positive Control 3

Jurkat

Positive Control 4

Raji

Positive Control 5

DU-145

Positive Control 6

Mouse kidney

NCBI Official Name

Frataxin, mitochondrial

NCBI Organism

Homo sapiens

Other Product Names

Frataxin, mitochondrial, Friedreich ataxia protein, Fxn, Frataxin intermediate form, i-FXN, Frataxin (56-210), m56-FXN, Frataxin (78-210), d-FXN, m78-FXN, Frataxin mature form, Frataxin (81-210), m81-FXN, FXN, FRDA, X25

Tested Applications

WB

Physical Properties

Liquid

Frequently Asked Questions

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