FXN / Frataxin Antibody, KO Validated
Product Specifications
Background
This nuclear gene encodes a mitochondrial protein which belongs to the FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA from 8-33 repeats to >90 repeats results in Friedreich ataxia. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
2395
Swiss Prot
Q16595
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 42-210 of human FXN / Frataxin (NP_000135.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Antibody is Knockout validated.
Field of Research
Signal Transduction
Purification
Affinity purification
Positive Control
K-562
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 14kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
FXN
Positive Control 2
U-87MG
Positive Control 3
Jurkat
Positive Control 4
Raji
Positive Control 5
DU-145
Positive Control 6
Mouse kidney
NCBI Official Name
Frataxin, mitochondrial
NCBI Organism
Homo sapiens
Other Product Names
Frataxin, mitochondrial, Friedreich ataxia protein, Fxn, Frataxin intermediate form, i-FXN, Frataxin (56-210), m56-FXN, Frataxin (78-210), d-FXN, m78-FXN, Frataxin mature form, Frataxin (81-210), m81-FXN, FXN, FRDA, X25
Tested Applications
WB
Physical Properties
Liquid
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