ASC / TMS1 Antibody

Product Specifications

Background

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD) . The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

29108

Swiss Prot

Q9ULZ3

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ASC / TMS1

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cancer, Cell Cycle

Purification

Affinity purification

Positive Control

HT-29

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 25kDa

Fragment

IgG

Symbol

PYCARD

Positive Control 2

BT-474

Positive Control 3

U-937

Positive Control 4

Mouse thymus

Positive Control 5

Mouse spleen

Positive Control 6

Rat spleen

NCBI Official Name

PYD and CARD domain containing

NCBI Organism

Homo sapiens

Other Product Names

ASC Antibody: ASC, TMS, TMS1, CARD5, TMS-1, ASC, Apoptosis-associated speck-like protein containing a CARD, Caspase recruitment domain-containing protein 5, hASC