ADRBK1 Antibody, KO Validated
Product Specifications
Background
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
NCBI Gene ID
156
Swiss Prot
P25098
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 440-689 of human ADRBK1 (NP_001610.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Antibody is Knockout validated.
Field of Research
Immunology, Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
HT-29
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 80kDa
Fragment
IgG
Symbol
ADRBK1
Positive Control 2
Mouse spleen
Positive Control 3
Mouse brain
NCBI Official Name
Adrenergic, beta, receptor kinase 1
NCBI Organism
Homo sapiens
Other Product Names
ADRBK1, adrenergic, beta, receptor kinase 1, BARK1, BETA-ARK1, GRK2, beta adrenergic receptor kinase 1, BARK
Tested Applications
WB, IHC
Physical Properties
Liquid
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