NEFM Antibody
Product Specifications
Background
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
NCBI Gene ID
4741
Swiss Prot
P07197
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human NEFM (NP_005373.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
MCF7
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 140kDa
Fragment
IgG
Symbol
NEFM
Positive Control 2
Rat brain
NCBI Official Name
Neurofilament, medium polypeptide
NCBI Organism
Homo sapiens
Other Product Names
NEFM, neurofilament-3 (150 kD medium), neurofilament, medium poly peptide 150 kDa, neurofilament triplet M protein, NFM, NF-M, NEF3, medium poly peptide, NEFM
Tested Applications
WB, IF
Physical Properties
Liquid
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