FGD1 Antibody
Product Specifications
Background
This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16.
NCBI Gene ID
2245
Swiss Prot
P98174
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 700-800 of human FGD1 (NP_004454.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
Affinity purification
Positive Control
U-87MG
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 110kDa
Fragment
IgG
Symbol
FGD1
Positive Control 2
BxPC-3
Positive Control 3
HepG2
Positive Control 4
U2OS
NCBI Official Name
FYVE, RhoGEF and PH domain containing 1
NCBI Organism
Homo sapiens
Other Product Names
FGD1, AAS, FGDY, MRXS16, ZFYVE3
Tested Applications
WB, IHC, IF
Physical Properties
Liquid
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