MBTPS1 Antibody
Product Specifications
Background
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction.
NCBI Gene ID
8720
Swiss Prot
Q14703
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 803-1052 of human MBTPS1 (NP_003782.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
Affinity purification
Positive Control
K-562
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=16-508
Calculated Molecular Weight
Observed: 117kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
MBTPS1
Positive Control 2
Mouse pancreas
NCBI Official Name
Membrane bound transcription factor peptidase, site 1
NCBI Organism
Homo sapiens
Other Product Names
PCSK8, S1P, SEDKF, SKI-1, membrane-bound transcription factor site-1 protease, endopeptidase S1P, proprotein convertase subtilisin/kexin type 8, site-1 protease, subtilisin/kexin isozyme-1
Tested Applications
WB
Physical Properties
Liquid
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