MBTPS1 Antibody

Product Specifications

Background

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction.

NCBI Gene ID

8720

Swiss Prot

Q14703

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 803-1052 of human MBTPS1 (NP_003782.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

Affinity purification

Positive Control

K-562

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 117kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

MBTPS1

Positive Control 2

Mouse pancreas

NCBI Official Name

Membrane bound transcription factor peptidase, site 1

NCBI Organism

Homo sapiens

Other Product Names

PCSK8, S1P, SEDKF, SKI-1, membrane-bound transcription factor site-1 protease, endopeptidase S1P, proprotein convertase subtilisin/kexin type 8, site-1 protease, subtilisin/kexin isozyme-1