DPYD Antibody
Product Specifications
Background
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
1806
Swiss Prot
Q12882
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-173 of human DPYD (NP_001153773.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Affinity purification
Positive Control
THP-1
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 112kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
DPYD
Positive Control 2
Mouse liver
NCBI Official Name
Dihydropyrimidine dehydrogenase
NCBI Organism
Homo sapiens
Other Product Names
DHP, DHPDHASE, DPD, dihydropyrimidine dehydrogenase [NADP (+) ], dihydrothymine dehydrogenase, dihydrouracil dehydrogenase
Tested Applications
WB
Physical Properties
Liquid
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