TriMethyl-Histone H3-K27 mAb
Product Specifications
Background
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4) . The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.
NCBI Gene ID
8290
Swiss Prot
Q16695
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic methylated peptide corresponding to residues surrounding K27 of human histone H3
Clonality
Monoclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Affinity purification
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
Methylated
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Fragment
IgG
Symbol
H3K27me3
NCBI Official Name
Histone cluster 3, H3
NCBI Organism
Homo sapiens
Other Product Names
H3F3A, H3t, H3.4, H3/g, H3FT
Tested Applications
WB, IHC, IF, IP, ChIP
Physical Properties
Liquid
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