IDO1 Antibody
Product Specifications
Background
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.
NCBI Gene ID
3620
Swiss Prot
P14902
Host
Rabbit
Reactivity
Human, Mouse, Monkey
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 204-403 of human IDO1 (NP_002155.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Signal Transduction
Purification
Affinity purification
Positive Control
HepG2
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 50kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
IDO1
Positive Control 2
293T
Positive Control 3
HeLa
Positive Control 4
COS-7
Positive Control 5
Mouse intestine
NCBI Official Name
Indoleamine 2,3-dioxygenase 1
NCBI Organism
Homo sapiens
Other Product Names
Indoleamine 2,3-dioxygenase; INDO
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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