MUTYH Antibody
Product Specifications
Background
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP) . Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
4595
Swiss Prot
Q9UIF7
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-265 of human MUTYH (NP_001041636.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity purification
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Fragment
IgG
Symbol
MUTYH
NCBI Official Name
MutY homolog
NCBI Organism
Homo sapiens
Other Product Names
MUTYH, MYH, mutY homolog (E. coli), mutY (E. coli) homolog
Tested Applications
IHC, IF
Physical Properties
Liquid
Frequently Asked Questions
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