DHFR Antibody
Product Specifications
Background
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
1719
Swiss Prot
P00374
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-187 of human DHFR (NP_000782.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 19kDa
Fragment
IgG
Symbol
DHFR
Positive Control 2
22Rv1
Positive Control 3
K-562
Positive Control 4
HL-60
Positive Control 5
THP-1
Positive Control 6
Raji
NCBI Official Name
Dihydrofolate reductase
NCBI Organism
Homo sapiens
Other Product Names
DHFRP1, DYR, dihydrofolate reductase
Tested Applications
WB, IF
Physical Properties
Liquid
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