MASP2 Antibody

Product Specifications

Background

This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

NCBI Gene ID

10747

Swiss Prot

O00187

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 445-686 of human MASP2 (NP_006601.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Innate Immunity

Purification

Affinity purification

Positive Control

HepG2

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 76kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

MASP2

Positive Control 2

U-87MG

Positive Control 3

Mouse liver

Positive Control 4

Rat kidney

NCBI Official Name

Mannan binding lectin serine peptidase 2

NCBI Organism

Homo sapiens

Other Product Names

MAP19, MASP-2, MASP1P1, sMAP, mannan-binding lectin serine protease 2, MBL-associated plasma protein of 19 kD, MBL-associated serine protease 2, mannan-binding lectin serine peptidase 1 pseudogene 1, mannan-binding lectin serine protease 1 pseudogene 1, mannose-binding protein-associated serine protease 2, small MBL-associated protein