HAMP Antibody

Product Specifications

Background

The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.

NCBI Gene ID

57817

Swiss Prot

P81172

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-84 of human HAMP (NP_066998.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Innate Immunity, Signal Transduction

Purification

Affinity purification

Positive Control

MDA-MB-435

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 10kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

HAMP

NCBI Official Name

Hepcidin antimicrobial peptide

NCBI Organism

Homo sapiens

Other Product Names

Putative liver tumor regressor, liver-expressed antimicrobial peptide, PLTR, LEAP1, LEAP-1, HFE2B, HEPCIDIN, HEPC, hepcidin antimicrobial peptide, HAMP, UNQ487/PRO1003