EDARADD Antibody

Product Specifications

Background

This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

NCBI Gene ID

128178

Swiss Prot

Q8WWZ3

Host

Rabbit

Reactivity

Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human EDARADD (NP_665860.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

Affinity purification

Positive Control

Mouse pancreas

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 25kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

EDARADD

NCBI Official Name

EDAR associated death domain

NCBI Organism

Homo sapiens

Other Product Names

ECTD11A, ECTD11B, ED3, EDA3, ectodysplasin-A receptor-associated adapter protein, EDAR-associated death domain protein, crinkled homolog, ectodysplasia A receptor associated death domain