UPF3A Antibody
Product Specifications
Background
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD) . When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene.
NCBI Gene ID
65110
Swiss Prot
Q9H1J1
Host
Rabbit
Reactivity
Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 327-476 of human UPF3A (NP_075387.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Affinity purification
Positive Control
Mouse testis
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=16-307
Calculated Molecular Weight
Observed: 55kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
UPF3A
NCBI Official Name
UPF3 regulator of nonsense transcripts homolog A (yeast)
NCBI Organism
Homo sapiens
Other Product Names
UPF3A, UPF3 regulator of nonsense transcripts homolog A, OTTHUMP00000018789, UPF3, RENT3A, HUPF3A, UPF3 regulator of nonsense transcripts homolog A (yeast), UPF3A
Tested Applications
WB
Physical Properties
Liquid
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