THRB Antibody
Product Specifications
Background
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH) . Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
NCBI Gene ID
7068
Swiss Prot
P10828
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human THRB (NP_000452.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Growth Factors, Neuroscience, Signal Transduction, Transcription
Purification
Affinity purification
Positive Control
HepG2
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 53kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
THRB
Positive Control 2
U-87MG
Positive Control 3
Mouse liver
Positive Control 4
Mouse eye
Positive Control 5
Rat liver
Positive Control 6
Rat eye
NCBI Official Name
Thyroid hormone receptor, beta
NCBI Organism
Homo sapiens
Other Product Names
THRB, GRTH, PRTH, THR1, ERBA2, NR1A2, THRB1, THRB2, C-ERBA-2, C-ERBA-BETA
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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