IL6R Antibody

Product Specifications

Background

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

NCBI Gene ID

3570

Swiss Prot

P08887

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human IL6R (NP_000556.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Chemokines & Cytokines, Immunology, Innate Immunity, Stem Cell

Purification

Affinity purification

Positive Control

SW480

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 52kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

IL6R

Positive Control 2

NCI-H460

Positive Control 3

HepG2

NCBI Official Name

Interleukin 6 receptor

NCBI Organism

Homo sapiens

Other Product Names

IL6R, interleukin 6 receptor, HGNC:6019, CD126, IL-6R-1, IL-6R-alpha, IL6RA, MGC104991, CD126 antigen, interleukin 6 receptor alpha subunit, IL6Q, gp80, IL6RQ, IL-6RA