TNFRSF18 Antibody
Product Specifications
Background
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
NCBI Gene ID
8784
Swiss Prot
Q9Y5U5
Host
Rabbit
Reactivity
Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 26-255 of human TNFRSF18 (NP_683699.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Chemokines & Cytokines, Growth Factors, Immunology, Innate Immunity, Signal Transduction
Purification
Affinity purification
Positive Control
Mouse thymus
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 30kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
TNFRSF18
NCBI Official Name
Tumor necrosis factor receptor superfamily, member 18
NCBI Organism
Homo sapiens
Other Product Names
TNFRSF18, AITR, GITR, CD357, GITR-D
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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