NTRK1 Antibody

Product Specifications

Background

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

NCBI Gene ID

4914

Swiss Prot

P04629

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 700 to the C-terminus of human NTRK1 (NP_002520.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Growth Factors, Neuroscience, Signal Transduction

Purification

Affinity purification

Positive Control

Mouse brain

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 140kDa

Fragment

IgG

Symbol

NTRK1

Positive Control 2

Rat brain

NCBI Official Name

Neurotrophic tyrosine kinase, receptor, type 1

NCBI Organism

Homo sapiens

Other Product Names

NTRK1, Oncogene TRK, TrkA/NGF receptor, Tropomyosin-related kinase A, TRK, TRK1, Tyrosine kinase receptor, Tyrosine kinase receptor A, gp140trk, MTC, p140-TrkA, Trk-A, TRKA