Lrwd1 Antibody

Product Specifications

Background

The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

222229

Swiss Prot

Q9UFC0

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 250-350 of human Lrwd1 (NP_690852.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

Affinity purification

Positive Control

U-87MG

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 65kDa

Fragment

IgG

Applications Notes

WB: 1:200 - 1:2000

Symbol

Lrwd1

Positive Control 2

HeLa

Positive Control 3

HepG2

Positive Control 4

Jurkat

Positive Control 5

Mouse testis

Positive Control 6

Mouse thymus

NCBI Official Name

Leucine rich repeats and WD repeat domain containing 1

NCBI Organism

Homo sapiens

Other Product Names

CENP-33, ORCA, leucine-rich repeat and WD repeat-containing protein 1, ORC-associated protein, centromere protein 33, origin recognition complex-associated protein, testicular tissue protein Li 4