TOP1MT Antibody
Product Specifications
Background
This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
NCBI Gene ID
116447
Swiss Prot
Q969P6
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 470-550 of human TOP1MT (NP_443195.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
Affinity purification
Positive Control
A-549
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 70kDa
Fragment
IgG
Applications Notes
WB: 1:200 - 1:2000
Symbol
TOP1MT
NCBI Official Name
DNA topoisomerase I mitochondrial
NCBI Organism
Homo sapiens
Other Product Names
DNA topoisomerase I, mitochondrial, mitochondrial topoisomerase IB, topoisomerase (DNA) I, mitochondrial
Tested Applications
WB
Physical Properties
Liquid
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