TNFR1 Antibody

Product Specifications

Background

This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients.

NCBI Gene ID

7132

Swiss Prot

P19438

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 22-211 of human TNFR1 (NP_001056.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cell Cycle, Chemokines & Cytokines, Growth Factors, Immunology, Innate Immunity, Neuroscience, Signal Transduction, Inflammasomes

Purification

Affinity purification

Positive Control

A-549

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 56kDa

Fragment

IgG

Symbol

TNFRSF1A

Positive Control 2

Mouse lung

NCBI Official Name

Tumor necrosis factor receptor superfamily, member 1A

NCBI Organism

Homo sapiens

Other Product Names

TNFRSF1A, tumor necrosis factor-alpha receptor, tumor necrosis factor receptor type 1, tumor necrosis factor receptor superfamily, member 1A, tumor necrosis factor receptor superfamily member 1A, tumor necrosis factor receptor 1A isoform beta, tumor necrosis factor binding protein 1, TNF-R-I, TNF-RI, TNFR-I, TNFR60, TNF-R55, TNFR55, TNF-R1, TNFR1, TNF-R, TNFAR, TBP1, p60, p55-R, p55, MGC19588, FPF, CD120a