Verubulin

Verubulin (MPC-6827) is a highly potent and broad-spectrum microtubule blocker. Verubulin has antitumor activity against breast cancer, melanoma, and ovarian cancer. Verubulin can be used in non-small cell lung cancer research[1][2][3].

Product Specifications

CAS Number

[827031-83-4]

Product Name Alternative

MPC 6827

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/verubulin.html

Purity

99.34

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=NC(N(C2=CC=C(OC)C=C2)C)=C3C=CC=CC3=N1

Molecular Formula

C17H17N3O

Molecular Weight

279.34

Precautions

H315, H319

References & Citations

[1]Kasibhatla S, et al. MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 2007 Jun 15;67 (12) :5865-71.|[2]Kasibhatla S, et al. MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 2007 Jun 15;67 (12) :5865-71.|[3]Jones J T, et al. Comparison of MPC-6827 activity in xenograft models with different dosing schedules. Journal of Clinical Oncology, 2011, 29 (15_suppl) : e13080-e13080.