Verubulin
Verubulin (MPC-6827) is a highly potent and broad-spectrum microtubule blocker. Verubulin has antitumor activity against breast cancer, melanoma, and ovarian cancer. Verubulin can be used in non-small cell lung cancer research[1][2][3].
Product Specifications
CAS Number
827031-83-4
Product Name Alternative
MPC 6827
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/verubulin.html
Purity
99.34
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=NC(N(C2=CC=C(OC)C=C2)C)=C3C=CC=CC3=N1
Molecular Formula
C17H17N3O
Molecular Weight
279.34
Precautions
H315, H319
References & Citations
[1]Kasibhatla S, et al. MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 2007 Jun 15;67 (12) :5865-71.|[2]Kasibhatla S, et al. MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 2007 Jun 15;67 (12) :5865-71.|[3]Jones J T, et al. Comparison of MPC-6827 activity in xenograft models with different dosing schedules. Journal of Clinical Oncology, 2011, 29 (15_suppl) : e13080-e13080.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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