SMG7 Antibody
Product Specifications
Background
This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD) ; a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
NCBI Gene ID
9887
Swiss Prot
Q92540
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SMG7 (NP_963863.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity purification
Positive Control
Jurkat
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=16-018
Calculated Molecular Weight
Observed: 127kDa
Fragment
IgG
Applications Notes
WB: 1:200 - 1:2000
Symbol
SMG7
Positive Control 2
Mouse testis
NCBI Official Name
SMG7 nonsense mediated mRNA decay factor
NCBI Organism
Homo sapiens
Other Product Names
C1orf16, EST1C, SGA56M, protein SMG7, EST1 telomerase component homolog C, EST1-like protein C, breast cancer-associated antigen SGA-56M, ever shorter telomeres 1C, smg-7 homolog, nonsense mediated mRNA decay factor
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
P100891_T100-Biotin 100 µL
TEAD1 Antibody - N-terminal region: Biotin (P100891_T100-Biotin)
Ask
View Details 