SMG7 Antibody

This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD) ; a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

C1orf16, EST1C, SGA56M, protein SMG7, EST1 telomerase component homolog C, EST1-like protein C, breast cancer-associated antigen SGA-56M, ever shorter telomeres 1C, smg-7 homolog, nonsense mediated mRNA decay factor