RTN3 Antibody
Product Specifications
Background
This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12.
NCBI Gene ID
10313
Swiss Prot
O95197
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human RTN3 (NP_006045.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cell Cycle, Signal Transduction
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=15-892
Calculated Molecular Weight
Observed: 26kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
RTN3
NCBI Official Name
Reticulon 3
NCBI Organism
Homo sapiens
Other Product Names
RTN3, ASYIP, ASY interacting protein, HAP, NSP-like protein II, NSPL2, RTN3-A1, NSP-like protein 2, Reticulon-3, Homolog of ASY protein, NSPLII, Reticulon 3
Tested Applications
WB
Physical Properties
Liquid
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