RTN3 Antibody

Product Specifications

Background

This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12.

NCBI Gene ID

10313

Swiss Prot

O95197

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human RTN3 (NP_006045.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cell Cycle, Signal Transduction

Purification

Affinity purification

Positive Control

HeLa

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 26kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

RTN3

NCBI Official Name

Reticulon 3

NCBI Organism

Homo sapiens

Other Product Names

RTN3, ASYIP, ASY interacting protein, HAP, NSP-like protein II, NSPL2, RTN3-A1, NSP-like protein 2, Reticulon-3, Homolog of ASY protein, NSPLII, Reticulon 3