SIM2 Antibody

Product Specifications

Background

This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants.

NCBI Gene ID

6493

Swiss Prot

Q14190

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 342-525 of human SIM2 (NP_033664.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Neuroscience, Transcription

Purification

Affinity purification

Positive Control

U-251MG

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 56kDa

Fragment

IgG

Symbol

SIM2

Positive Control 2

HepG2

NCBI Official Name

Single-minded family bHLH transcription factor 2

NCBI Organism

Homo sapiens

Other Product Names

Single-minded homolog 2, short isoform, single-minded homolog 2, class E basic helix-loop-helix protein 15, OTTHUMP00000109044, bHLHe15, SIM, MGC119447, single-minded homolog 2 (Drosophila), SIM2, BHLHE15