ARNT Antibody
Product Specifications
Background
This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
405
Swiss Prot
P27540
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ARNT (NP_001659.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction, Transcription
Purification
Affinity purification
Positive Control
SH-SY5Y
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=15-676
Calculated Molecular Weight
Observed: 87kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
ARNT
Positive Control 2
Mouse brain
Positive Control 3
Rat brain
NCBI Official Name
Aryl hydrocarbon receptor nuclear translocator
NCBI Organism
Homo sapiens
Other Product Names
ARNT, aryl hydrocarbon receptor nuclear translocator, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2, OTTHUMP00000218217, OTTHUMP00000218218, OTTHUMP00000218220, class E basic helix-loop-helix protein 2, dioxin receptor, nuclear transloc
Tested Applications
WB
Physical Properties
Liquid
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