CISH Antibody
Product Specifications
Background
The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
1154
Swiss Prot
Q9NSE2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 17-130 of human CISH (NP_659508.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
Affinity purification
Positive Control
293T
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=15-585
Calculated Molecular Weight
Observed: 37kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
CISH
NCBI Official Name
Cytokine inducible SH2 containing protein
NCBI Organism
Homo sapiens
Other Product Names
BACTS2, CIS, CIS-1, G18, SOCS, cytokine-inducible SH2-containing protein, cytokine-inducible inhibitor of signaling type 1B, suppressor of cytokine signaling
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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