GPNMB Antibody
Product Specifications
Background
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
10457
Swiss Prot
Q14956
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 22-260 of human GPNMB (NP_001005340.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Innate Immunity
Purification
Affinity purification
Positive Control
A-549
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 64kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
GPNMB
Positive Control 2
K-562
Positive Control 3
U-87MG
Positive Control 4
Mouse brain
Positive Control 5
Mouse liver
Positive Control 6
Rat brain
NCBI Official Name
Glycoprotein (transmembrane) nmb
NCBI Organism
Homo sapiens
Other Product Names
GPNMB, HGFIN, NMB
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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